Exosomal circGSE1 promotes immune escape of hepatocellular carcinoma by inducing the expansion of regulatory T cells.

ABSTRACT: Studies have shown exosomal circRNAs can regulate the immune escape of tumors by carrying cancer-derived molecules. Regulatory T cells (Tregs) participate in the process of tumor immune escape. However, the mechanism by which exosomal circRNAs regulate Tregs to create a microenvironment for tumor immune escape is unclear. The effect of exosomes on the proliferation, migration, and invasion of tumor cells was evaluated by CCK-8, transwell, and wound-healing assays. The expression of circGSE1 was evaluated by real-time quantitative PCR, and the function of exosomal circGSE1 was explored by Western blot and RNA pull-down assays. In vivo animal metastasis models and bioluminescence imaging were used to verify the effect of exosomal circGSE1 on tumor progression. Collectively, we revealed that

SUBMITTER: Huang M 

PROVIDER: S-EPMC9207376 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature