Predicted Vancomycin Dosage Requirement in Patients With Hematological Malignancies and Dosage Dynamic Adjustment.

ABSTRACT: Purpose: The purpose of this study was 1) to predict the requisite vancomycin daily dose (D _van ) used in the target patients suffering from both bacterial infection and hematological malignancies and 2) to construct a vancomycin-dose-graphical tool to assist clinicians to develop vancomycin dosing regimens and further 3) to establish a programming process for vancomycin dynamic dosage adjustment to help clinicians to adjust vancomycin dosing regimens according to physiological and pathogenic factors of the target patients. Methods: The D _van model associated with microbial susceptibility, vancomycin pharmacokinetics, and dosing parameters was established, and the D _van was estimated based on the estab

SUBMITTER: Song X 

PROVIDER: S-EPMC9207402 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature