Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease.

ABSTRACT: Conventional functional MRI (fMRI) with blood-oxygenation level dependent (BOLD) contrast is an important tool for mapping human brain activity non-invasively. Recent interest in quantitative fMRI has renewed the importance of oxidative neuroenergetics as reflected by cerebral metabolic rate of oxygen consumption (CMR_O2) to support brain function. Dynamic CMR_O2 mapping by calibrated fMRI require multi-modal measurements of BOLD signal along with cerebral blood flow (CBF) and/or volume (CBV). In human subjects this "calibration" is typically performed using a gas mixture containing small amounts of carbon dioxide and/or oxygen-enriched medical air, which are thought to produce changes in CBF (and CBV) and BOLD signal with minimal or no CMR_O2 changes. However

SUBMITTER: Chen JJ 

PROVIDER: S-EPMC9207484 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature