A flow-diffusion model of oxygen transport for quantitative mapping of cerebral metabolic rate of oxygen (CMRO₂) with single gas calibrated fMRI.

ABSTRACT: One promising approach for mapping CMRO₂ is dual-calibrated functional MRI (dc-fMRI). This method exploits the Fick Principle to combine estimates of CBF from ASL, and OEF derived from BOLD-ASL measurements during arterial O₂ and CO₂ modulations. Multiple gas modulations are required to decouple OEF and deoxyhemoglobin-sensitive blood volume. We propose an alternative single gas calibrated fMRI framework, integrating a model of oxygen transport, that links blood volume and CBF to OEF and creates a mapping between the maximum BOLD signal, CBF and OEF (and CMRO₂). Simulations demonstrated the method's viability within physiological ranges of mitochondrial oxygen pressure, P_mO₂, and mean capillary transit time. A dc-fMRI experi

SUBMITTER: Chiarelli AM 

PROVIDER: S-EPMC9207485 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature