Assessment of motion and model bias on the detection of dopamine response to behavioral challenge.

ABSTRACT: Compartmental modeling analysis of ¹¹C-raclopride (RAC) PET data can be used to measure the dopaminergic response to intra-scan behavioral tasks. Bias in estimates of binding potential (BP_ND) and its dynamic changes (ΔBP_ND) can arise both when head motion is present and when the compartmental model used for parameter estimation deviates from the underlying biology. The purpose of this study was to characterize the effects of motion and model bias within the context of a behavioral task challenge, examining the impacts of different mitigation strategies. Seventy healthy adults were administered bolus plus constant infusion RAC during a simultaneous PET/magnetic resonance (MR) scan with a reward task experiment. BP_ND and ΔBP_ND were estim

SUBMITTER: Levine MA 

PROVIDER: S-EPMC9207487 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature