Changes in neurovascular coupling with cerebral perfusion pressure indicate a link to cerebral autoregulation.

ABSTRACT: Cerebral autoregulation ensures a stable average blood supply to brain tissue across steady state cerebral perfusion pressure (CPP) levels. Neurovascular coupling, in turn, relies on sufficient blood flow to meet neuronal demands during activation. These mechanisms break down in pathologies where extreme levels of CPP can cause dysregulation in cerebral blood flow. Here, we experimentally tested the influence of changes in CPP on neurovascular coupling in a hydrocephalus-type non-human primate model (n = 3). We recorded local neural and vascular evoked responses to a checkerboard visual stimulus, non-invasively, using electroencephalography and near-infrared spectroscopy respectively. The evoked signals showed changes in various waveform features in the visual evoked potentials and the hem

SUBMITTER: Acharya D 

PROVIDER: S-EPMC9207489 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature