Impact of meningeal uptake and partial volume correction techniques on [¹⁸F]MK-6240 binding in aMCI patients and healthy controls.

ABSTRACT: [¹⁸F]MK-6240 is a second-generation tau PET-tracer to quantify neurofibrillary tangles in-vivo. However, individually variable levels of meningeal uptake induce spill-in-effects into the cortex, complicating [¹⁸F]MK-6240 PET quantification. Group SUVR differences between age-matched HC subgroups with varying extracerebral uptake (EC-low/mixed/high), and between aMCI and each HC subgroup were assessed without and with partial volume correction (PVC). Both Müller-Gartner (MG-)PVC and region-based voxelwise (RBV-)PVC, with the latter also correcting for extracerebral spill-in-effects, were implemented. Between HC groups, where no differences are to be expected, HC EC-high showed spill-in differences compared to HC EC-low when no PVC was applied while for MG-PVC, differen

SUBMITTER: Mertens N 

PROVIDER: S-EPMC9207493 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature