Radiomic Signatures for Predicting Receptor Status in Breast Cancer Brain Metastases.

ABSTRACT:

Backgrounds

A significant proportion of breast cancer patients showed receptor discordance between primary cancers and breast cancer brain metastases (BCBM), which significantly affected therapeutic decision-making. But it was not always feasible to obtain BCBM tissues. The aim of the present study was to analyze the receptor status of primary breast cancer and matched brain metastases and establish radiomic signatures to predict the receptor status of BCBM.

Methods

The receptor status of 80 matched primary breast cancers and resected brain metastases were retrospectively analyzed. Radiomic features were extracted using preoperative brain MRI (contrast-enhanced T1-weighted imaging, T2-weighted imaging, T2 fluid-attenuated inversion recovery, and combinations of these sequenc

SUBMITTER: Luo X 

PROVIDER: S-EPMC9207517 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature