A nested case-control study on radiation dose-response for cardiac events in breast cancer patients in Germany.

ABSTRACT:

Background

Previous studies with the majority of breast cancer (BC) patients treated up to 2000 provided evidence that radiation dose to the heart from radiotherapy (RT) was linearly associated with increasing risk for long-term cardiac disease. RT techniques changed substantially over time. This study aimed to investigate the dose-dependent cardiac risk in German BC patients treated with more contemporary RT.

Methods

In a cohort of 11,982 BC patients diagnosed in 1998-2008, we identified 494 women treated with 3D-conformal RT who subsequently developed a cardiac event. Within a nested case-control approach, these cases were matched to 988 controls. Controls were patients without a cardiac event after RT until the index date of the corresponding case. Separate multivariable

SUBMITTER: Baaken D 

PROVIDER: S-EPMC9207715 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature