Bioactive hydrogel coatings of complex substrates using diffusion-mediated redox initiation.

ABSTRACT: Hydrogels have long been established as materials with tunable stiffness and chemistry that enable controlled cellular interactions. When applied as coatings, hydrogels can be used to introduce biofunctionality to medical devices with minimal effect on bulk properties. However, it remains challenging to uniformly apply hydrogel coatings to three dimensional geometries without substantially changing the manufacturing process and potentially affecting device function. Herein, we report a new redox-based crosslinking method for applying conformable hydrogel coatings with tunable thickness and chemistry. This new diffusion-mediated strategy of redox initiation and hydrogel crosslinking enabled coating of a variety of three dimensional substrates without changing the primary fabrication process

SUBMITTER: Wancura M 

PROVIDER: S-EPMC9207961 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature