Normalization effect of levodopa on hierarchical brain function in Parkinson's disease.

ABSTRACT: Hierarchical brain organization, in which the rich club and diverse club situate in core position, is critical for global information integration in the human brain network. Parkinson's disease (PD), a common movement disorder, has been conceptualized as a network disorder. Levodopa is an effective treatment for PD. Whether there is a functional divergence in the hierarchical brain system under PD pathology, and how this divergence is regulated by immediate levodopa therapy, remains unknown. We constructed a functional network in 61 PD patients and 89 normal controls and applied graph theoretical analyses to examine the neural mechanism of levodopa short response from the perspective of brain hierarchical configuration. The results revealed the following: (a) PD patients exhibited disrupte

SUBMITTER: Guo T 

PROVIDER: S-EPMC9208001 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature