Multi-spatial-scale dynamic interactions between functional sources reveal sex-specific changes in schizophrenia.

ABSTRACT: We introduce an extension of independent component analysis (ICA), called multiscale ICA, and design an approach to capture dynamic functional source interactions within and between multiple spatial scales. Multiscale ICA estimates functional sources at multiple spatial scales without imposing direct constraints on the size of functional sources, overcomes the limitation of using fixed anatomical locations, and eliminates the need for model-order selection in ICA analysis. We leveraged this approach to study sex-specific and sex-common connectivity patterns in schizophrenia. Results show dynamic reconfiguration and interaction within and between multi-spatial scales. Sex-specific differences occur (a) within the subcortical domain, (b) between the somatomotor and cerebellum domains, and (c

SUBMITTER: Iraji A 

PROVIDER: S-EPMC9208002 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature