Peripartum disease activity in moderately and severely disabled women with multiple sclerosis.

ABSTRACT:

Background

The effects of pregnancy on multiple sclerosis (MS) inflammatory activity are not well described in women with moderate to severe disabilities.

Objective

To quantify the peripartum annualized relapse rate (ARR) in women with MS with an Expanded Disability Status Scale (EDSS) ≥ 3.

Methods

We performed a retrospective cohort study of 85 pregnancies in 74 subjects with preconception EDSS ≥ 3. We quantified peripartum ARR and tested for risk factors predictive of peripartum relapses, postpartum brain magnetic resonance imaging activity (new T2 or gadolinium-enhancing lesions), and disability worsening.

Results

There were 74 live births, with a 56% operative delivery rate. In subjects with relapsing-remitting MS, ARR decreased to 0.11 during the third tri

SUBMITTER: Ostrem BL 

PROVIDER: S-EPMC9208060 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature