HLA-E restricted cytomegalovirus UL40 peptide polymorphism may represent a risk factor following congenital infection.

ABSTRACT:

Background

Congenital cytomegalovirus immunopathogenesis is largely unknown and multifactorial due to the complex interactions between viral, maternal, placental, and child factors. Polymorphisms in the HLA-E binding UL40_15-23 peptide mimics HLA-E complexed peptides from certain HLA-A, -B, -C and -G alleles, which regulate the cellular immune response driven by natural killer-cells (NK) and CD8 + T cells. The aim of this study was to compare UL40_15-23 peptides distribution in congenital CMV and the counterpart HLA Class I peptides in a healthy cohort to investigate risk factors and markers for cCMV disease. In this 10-year retrospective study, the UL40 gene was directly sequenced from 242 clinical samples from 199 cases of congenital CMV (166 children and 33 p

SUBMITTER: Tarrago D 

PROVIDER: S-EPMC9208114 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature