Mechanism of reduced muscle atrophy via ketone body (D)-3-hydroxybutyrate.

ABSTRACT:

Background

Muscle atrophy is an increasingly global health problem affecting millions, there is a lack of clinical drugs or effective therapy. Excessive loss of muscle mass is the typical characteristic of muscle atrophy, manifesting as muscle weakness accompanied by impaired metabolism of protein and nucleotide. (D)-3-hydroxybutyrate (3HB), one of the main components of the ketone body, has been reported to be effective for the obvious hemodynamic effects in atrophic cardiomyocytes and exerts beneficial metabolic reprogramming effects in healthy muscle. This study aims to exploit how the 3HB exerts therapeutic effects for treating muscle atrophy induced by hindlimb unloaded mice.

Results

Anabolism/catabolism balance of muscle protein was maintained with 3HB via the Akt/FoxO

SUBMITTER: Chen J 

PROVIDER: S-EPMC9208164 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature