¹⁸F-FDG and ⁶⁸ Ga-FAPI PET/CT for the evaluation of periprosthetic joint infection and aseptic loosening in rabbit models.

ABSTRACT:

Purpose

We built a joint replacement loosening model based on the original rabbit model of infection and evaluated the performance characteristics of ¹⁸F-FDG and ⁶⁸ Ga-FAPI in evaluating infection and loosening.

Methods

After surgery, the rabbits were divided into four groups, with six individuals in the control group and 10 each in the aseptic loosening, S. aureus and S. epidermidis groups. PET/CT and serological examination were performed three times at two-week intervals. After the rabbits were euthanized, micro-CT, tissue pathology, pullout tests and scanning electron microscopy (SEM) were performed.

Results

The pullout test and SEM showed the feasibility of the aseptic loosening model. ¹⁸F-FDG showed similar performance in the con

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9208226 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature