A Cu^II -Salicylidene Glycinato Complex for the Selective Fluorometric Detection of Homocysteine over 20 Proteinogenic Amino Acids.

ABSTRACT: Homocysteine (Hcy) is a sulfur-containing α-amino acid that differs by one methylene (CH₂ ) subunit from homologous cysteine (Cys). Elevated levels of Hcy are diagnostic markers of cardiovascular disease and other medical conditions. We present a new Cu^II -salicylidene glycinato complex 1 for the selective fluorometric detection of Hcy in water. In the presence of this analyte, the non-fluorescent copper-complex demetallates and disassembles into its building blocks. This process liberates a 3-chloro-5-sulfosalicylaldehyde signaling unit and is accompanied by a 51-fold turn-on fluorescence at 485 nm (λ_ex =350 nm). Out of twenty proteinogenic amino acids, only histidine (12-fold turn-on fluorescence) and Cys (8-fold turn-on fluorescence) trigger some disasse

SUBMITTER: Li X 

PROVIDER: S-EPMC9208288 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature