An Operative Electrostatic Slipping Mechanism along Macrocycle Flexibility Accelerates Guest Sliding during pseudo-Rotaxane Formation.

ABSTRACT: A pseudo-rotaxane is a host-guest complex composed of a linear molecule encircled by a macrocyclic ring. These complexes can be assembled by sliding the host over the guest terminal groups. If there is a close match between the molecular volume of the flanking groups on the guest and the cavity size of the macrocycle, the slipping might occur slowly or even become completely hindered. We have previously shown that it is possible to overcome the restraints imposed by steric effects on the sliding process by integrating electrostatic attractive interactions during the slipping step. In this work, we extend our electrostatically assisted slipping approach (EASA) to a new host-guest system featuring a flexible macrocyclic ring and a series of asymmetric guests containing a cyclic tertiary ammo

SUBMITTER: Catalan AC 

PROVIDER: S-EPMC9208289 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature