Anticipatory human subthalamic area beta-band power responses to dissociable tastes correlate with weight gain.

ABSTRACT: The availability of enticing sweet, fatty tastes is prevalent in the modern diet and contribute to overeating and obesity. In animal models, the subthalamic area plays a role in mediating appetitive and consummatory feeding behaviors, however, its role in human feeding is unknown. We used intraoperative, subthalamic field potential recordings while participants (n = 5) engaged in a task designed to provoke responses of taste anticipation and receipt. Decreased subthalamic beta-band (15-30 Hz) power responses were observed for both sweet-fat and neutral tastes. Anticipatory responses to taste-neutral cues started with an immediate decrease in beta-band power from baseline followed by an early beta-band rebound above baseline. On the contrary, anticipatory responses to sweet-fat were charact

SUBMITTER: Kakusa B 

PROVIDER: S-EPMC9208339 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature