Sex-specific associations of asthma acquisition with changes in DNA methylation during adolescence.

ABSTRACT:

Background

Underlying biological mechanisms involved in sex differences in asthma status changes from pre- to post-adolescence are unclear. DNA methylation (DNAm) has been shown to be associated with the risk of asthma.

Objective

We hypothesized that asthma acquisition from pre- to post-adolescence was associated with changes in DNAm during this period at asthma-associated cytosine-phosphate-guanine (CpG) sites and such an association was sex-specific.

Methods

Subjects from the Isle of Wight birth cohort (IOWBC) with DNAm in blood at ages 10 and 18 years (n = 124 females, 151 males) were studied. Using a training-testing approach, epigenome-wide CpGs associated with asthma were identified. Logistic regression was used to examine sex-specific associations of DNAm chang

SUBMITTER: Patel R 

PROVIDER: S-EPMC9208368 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature