Cost-effectiveness of rotavirus vaccination in children under five years of age in 195 countries: A meta-regression analysis.

ABSTRACT:

Background

Rotavirus caused an estimated 151,714 deaths from diarrhea among children under 5 in 2019. To reduce mortality, countries are considering adding rotavirus vaccination to their routine immunization program. Cost-effectiveness analyses (CEAs) to inform these decisions are not available in every setting, and where they are, results are sensitive to modeling assumptions, especially about vaccine efficacy. We used advances in meta-regression methods and estimates of vaccine efficacy by location to estimate incremental cost-effectiveness ratios (ICERs) for rotavirus vaccination in 195 countries.

Methods

Beginning with Tufts University CEA and Global Health CEA registries we used 515 ICERs from 68 articles published through 2017, extracted 938 additional one-way sensitiv

SUBMITTER: Janko MM 

PROVIDER: S-EPMC9208428 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature