Untargeted metabolomics profiling in a mouse model of lung cancer treated with thermal ablation.

ABSTRACT: Thermal ablation is widely used in the treatment of lung cancer and is beneficial for the overall survival of patients in clinic. However, there is barely a priority in which ablation system should be chosen under different periods of tumor progression in lung cancer. The present study investigated different modes of thermal ablation systems in mice with transplanted Lewis lung carcinoma tumors and their various biological effects in local regions using untargeted metabolomics. The results showed that thermal ablation could significantly suppress tumor growth and the differentially expressed metabolites of tumors after ablation relative to untreated tumors concentrated on organic compounds, organic acids and derivatives, nucleosides, nucleotides, and lipids. The upregulated metabolites ind

SUBMITTER: Pang H 

PROVIDER: S-EPMC9208470 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature