Evaluation of cerebral cortex viscoelastic property estimation with nonlinear inversion magnetic resonance elastography.

ABSTRACT: Objective. Magnetic resonance elastography (MRE) of the brain has shown promise as a sensitive neuroimaging biomarker for neurodegenerative disorders; however, the accuracy of performing MRE of the cerebral cortex warrants investigation due to the unique challenges of studying thinner and more complex geometries.Approach. A series of realistic, whole-brain simulation experiments are performed to examine the accuracy of MRE to measure the viscoelasticity (shear stiffness,μ, and damping ratio, ξ) of cortical structures predominantly effected in aging and neurodegeneration. Variations to MRE spatial resolution and the regularization of a nonlinear inversion (NLI) approach are examined.Main results. Higher-resolution MRE displacement data (1.25 mm isotropic resoluti

SUBMITTER: Hiscox LV 

PROVIDER: S-EPMC9208651 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature