Ten-year changes in plasma L-carnitine levels and risk of coronary heart disease.

ABSTRACT:

Purpose

L-Carnitine is abundant in animal source foods, particularly red meat, and circulating L-carnitine may be related to the incidence of coronary heart disease (CHD). We investigated whether long-term changes in plasma L-carnitine over 10 years were associated with the CHD incidence and also examined joint associations of carnitine-rich red meat consumption and L-carnitine changes on the subsequent risk of CHD.

Methods

This prospective nested case-control study included 772 healthy women at baseline (386 incident CHD cases and 386 healthy controls). Plasma L-carnitine levels were measured both at the first (1989-90) and second blood collections (2000-02). Incident cases of CHD were prospectively followed from the date of the second blood collection through 2016.

Resu

SUBMITTER: Heianza Y 

PROVIDER: S-EPMC9208674 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature