Beta-amyloid moderates the relationship between cortical thickness and attentional control in middle- and older-aged adults.

ABSTRACT: Although often unmeasured in studies of cognition, many older adults possess Alzheimer disease (AD) pathologies such as beta-amyloid (Aβ) deposition, despite being asymptomatic. We were interested in examining whether the behavior-structure relationship observed in later life was altered by the presence of preclinical AD pathology. A total of 511 cognitively unimpaired adults completed magnetic resonance imaging and three attentional control tasks; a subset (n = 396) also underwent Aβ-positron emissions tomography. A vertex-wise model was conducted to spatially represent the relationship between cortical thickness and average attentional control accuracy, while moderation analysis examined whether Aβ deposition impacted this relationship. First, we found that reduced cortical thickness in

SUBMITTER: McKay NS 

PROVIDER: S-EPMC9208719 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature