Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina.

ABSTRACT: Migration of cells in the developing brain is integral for the establishment of neural circuits and function of the central nervous system. While migration modes during which neurons employ predetermined directional guidance of either preexisting neuronal processes or underlying cells have been well explored, less is known about how cells featuring multipolar morphology migrate in the dense environment of the developing brain. To address this, we here investigated multipolar migration of horizontal cells in the zebrafish retina. We found that these cells feature several hallmarks of amoeboid-like migration that enable them to tailor their movements to the spatial constraints of the crowded retina. These hallmarks include cell and nuclear shape changes, as well as persistent rearward polari

SUBMITTER: Amini R 

PROVIDER: S-EPMC9208757 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature