Serum glucose-regulated protein 78 (GRP78) levels in COVID-19-associated mucormycosis: results of a case–control study

ABSTRACT:

Background

In experimental models, the expression of glucose-regulated protein 78 (GRP78) in endothelial cells played a role in the pathogenesis of mucormycosis. However, the role of GRP78 in COVID-19-associated mucormycosis (CAM) has not been studied. We hypothesized that serum GRP78 levels are elevated in subjects with CAM.

Objective

To compare the serum GRP78 levels in subjects with CAM and COVID-19 controls without mucormycosis.

Design And Setting

We performed a hospital-based, case–control study between 1 April 2021 and 31 May 2021.

Participants

We enrolled 24 subjects each of CAM and COVID-19 subjects without mucormycosis. We also measured serum GRP78 levels in ten healthy controls.

Exposure

The primary exposure studied was serum GRP78 con

SUBMITTER: Muthu V 

PROVIDER: S-EPMC9209319 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature