The Treasury of Wharton's Jelly.

ABSTRACT:

Background

Postnatal umbilical cord tissue contains valuable mesenchymal progenitor cells of various differentiation stages. While mesenchymal stem cells are plastic-adherent and tend to differentiate into myofibroblastic phenotypes, some round cells detach, float above the adherent cells, and build up cell aggregates, or form spheroids spontaneously. Very small luminescent cells are always involved as single cells or within collective forms and resemble the common well-known very small embryonic-like cells (VSELs). In this study, we investigated these VSELs-like cells in terms of their pluripotency phenotype and tri-lineage differentiation potential.

Methods

VSELs-like cells were isolated from cell-culture supernatants by a process that combines filtering, up concentration,

SUBMITTER: Guenther R 

PROVIDER: S-EPMC9209346 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature