Inflammasomes and the IL-1 Family in Bone Homeostasis and Disease.

ABSTRACT:

Purpose of review

Inflammasomes are multimeric protein structures with crucial roles in host responses against infections and injuries. The importance of inflammasome activation goes beyond host defense as a dysregulated inflammasome and subsequent secretion of IL-1 family members is believed to be involved in the pathogenesis of various diseases, some of which also produce skeletal manifestations. The purpose of this review is to summarize recent developments in the understanding of inflammasome regulation and IL-1 family members in bone physiology and pathology and current therapeutics will be discussed.

Recent findings

Small animal models have been vital to help understand how the inflammasome regulates bone dynamics. Animal models with gain or loss of function in various

SUBMITTER: Tseng HW 

PROVIDER: S-EPMC9209354 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature