Cognition as a mediator for gait and balance impairments in GBA-related Parkinson's disease.

ABSTRACT: The extent to which the heterogeneity of gait and balance problems in PD may be explained by genetic variation is unknown. Variants in the glucocerebrosidase (GBA) gene are the strongest known genetic risk factor for PD and are associated with greater motor and cognitive severity. However, the impact of GBA variants on comprehensive measures of gait and balance and their relationship to cognition remains unknown. We aimed to determine differences in gait and balance impairments in those with and without GBA variants (mutation carriers and E326K polymorphism) and explore direct and indirect effects of GBA status on gait, balance, and cognition. 332 participants, 43 of whom had GBA variants, were recruited. Participants completed a comprehensive, objective assessment of gait and standing bal

SUBMITTER: Morris R 

PROVIDER: S-EPMC9209443 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature