Effect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases.

ABSTRACT: Dietary fatty acids (FA) are components of the lipids, which contribute to membrane structure, energy input, and biological functions related to cellular signaling and transcriptome regulation. However, the consumers still associate dietary FA with fat deposition and increased occurrence of metabolic diseases such as obesity and atherosclerosis. Previous studies already demonstrated that some fatty acids are linked with inflammatory response, preventing metabolic diseases. To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. The key TF were identified by functional enrichment

SUBMITTER: Fanalli SL 

PROVIDER: S-EPMC9209463 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature