A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease, the most common cause of dementia, causes a progressive and irreversible deterioration of cognition that can sometimes be difficult to diagnose, leading to suboptimal patient care.

Methods

We developed a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted MRI scans, with or without cognitive scores. For each patient, a biomarker called "Alzheimer's Predictive Vector" (ApV) was derived using a two-stage least absolute shrinkage and selection operator (LASSO).

Results

The ApV reliably discriminates between people with (ADrp) and without (nADrp) Alzheimer's related pathologies (98% and 81% accuracy between ADrp - including the early form, mild cognitive impairment - and nADrp in in

SUBMITTER: Inglese M 

PROVIDER: S-EPMC9209493 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature