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Alpha-1-Antitrypsin Experience for Steroid-Resistant Acute Graft-Versus-Host Disease.

ABSTRACT: Steroid-refractory acute graft-versus-host disease (SR-aGVHD) treatment has a low response rate and a high risk of infection in allogeneic hematopoietic stem cell transplantation. The standard approach to be applied in this situation is uncertain. This study aims to evaluate the effectiveness and safety of alpha-1-antitrypsin (AAT). In the study, the results of five SR-aGVHD patients received AAT evaluated. Complete response was seen 2 of four patients with gastrointestinal (GI) aGVHD, partial response in one GI and one liver aGVHD. The overall response rate was 80%. AAT is an effective and safe treatment option in SR-aGVHD.

SUBMITTER: Koyun D

PROVIDER: S-EPMC9209553 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Alpha-1-Antitrypsin Experience for Steroid-Resistant Acute Graft-Versus-Host Disease.

Koyun Derya D Seval Güldane Cengiz GC Kırcalı Ekin E Bozdağ Sinem Civriz SC Toprak Selami Koçak SK Topçuoğlu Pervin P Özcan Muhit M Arslan Önder Ö Demirer Taner T İlhan Osman O Beksaç Meral M Gürman Günhan G Yüksel Meltem Kurt MK

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion 20220207 3

Steroid-refractory acute graft-versus-host disease (SR-aGVHD) treatment has a low response rate and a high risk of infection in allogeneic hematopoietic stem cell transplantation. The standard approach to be applied in this situation is uncertain. This study aims to evaluate the effectiveness and safety of alpha-1-antitrypsin (AAT). In the study, the results of five SR-aGVHD patients received AAT evaluated. Complete response was seen 2 of four patients with gastrointestinal (GI) aGVHD, partial r ...[more]

PMID: 35747565

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