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Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion.

ABSTRACT: 16p11.2 copy number variations have been associated with neurodevelopmental disorders. Human induced pluripotent stem cells were generated from fibroblasts obtained from a patient diagnosed with schizophrenia with a 16p11.2 deletion. The generated cell line was further validated for its pluripotency and potential to differentiate into the three germ layers.

SUBMITTER: Madencioglu DA

PROVIDER: S-EPMC9209596 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion.

Madencioglu Deniz A DA Kruth Karina K Shin Mallory M Andreasen Nancy N Wassink Thomas T Williams Aislinn A

Stem cell research 20211221

16p11.2 copy number variations have been associated with neurodevelopmental disorders. Human induced pluripotent stem cells were generated from fibroblasts obtained from a patient diagnosed with schizophrenia with a 16p11.2 deletion. The generated cell line was further validated for its pluripotency and potential to differentiate into the three germ layers. ...[more]

PMID: 34953327

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