Sex-specific differences in cardiac function, inflammation and injury during early polymicrobial sepsis.

ABSTRACT:

Background

Sex differences in sepsis are underexplored and incompletely understood. Cardiac function in early sepsis is pivotal in determining survival; hyperdynamic left ventricular ejection fraction is associated with higher mortality. Female sex may be cardioprotective, but variable experimental findings have not controlled for hypovolaemia. Sex-specific local cardiac versus peripheral inflammation in causing cardiovascular dysfunction also remain unclear. We therefore examined whether there are sex-specific differences in cardiac function in early sepsis, controlling for volaemic status and sex-specific differences in the peripheral inflammatory response initiated by tumour necrosis factor (TNFα).

Methods

We used an experimental polymicrobial sepsis (faecal slurry) model

SUBMITTER: Walker SLM 

PROVIDER: S-EPMC9209626 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature