Heterogeneity Analysis of Bladder Cancer Based on DNA Methylation Molecular Profiling.

ABSTRACT: Bladder cancer is a highly complex and heterogeneous malignancy. Tumor heterogeneity is a barrier to effective diagnosis and treatment of bladder cancer. Human carcinogenesis is closely related to abnormal gene expression, and DNA methylation is an important regulatory factor of gene expression. Therefore, it is of great significance for bladder cancer research to characterize tumor heterogeneity by integrating genetic and epigenetic characteristics. This study explored specific molecular subtypes based on DNA methylation status and identified subtype-specific characteristics using patient samples from the TCGA database with DNA methylation and gene expression were measured simultaneously. The results were validated using an independent cohort from GEO database. Four DNA methylation molecu

SUBMITTER: Wang S 

PROVIDER: S-EPMC9209659 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature