Echo-guided left ventricular assist device speed optimisation for exercise maximisation.

ABSTRACT:

Objective

Current generation left ventricular assist devices (LVADs) operate with a fixed rotation speed and no automated speed adjustment function. This study evaluates the concept of physiological pump speed optimisation based on aortic valve opening (AVO) imaging during a cardiopulmonary exercise test (CPET).

Methods

This prospective crossover study (NCT05063006) enrolled patients with implanted third-generation LVADs with hydrodynamic bearing. After resting speed optimisation, patients were randomised to a fixed-modified speed or modified-fixed speed CPET sequence. Fixed speed CPET maintained baseline pump settings. During the modified speed CPET, the LVAD speed was continuously altered to preserve periodic AVO.

Results

We included 22 patients, the mean age was 58

SUBMITTER: Stapor M 

PROVIDER: S-EPMC9209671 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature