Mechanism of action involved in the anxiolytic-like effects of Hibalactone isolated from Hydrocotyle umbellata L.

ABSTRACT:

Background and aim

Hibalactone (HB) is a lignan related to the anxiolytic-like effects of Hydrocotyle umbellata L. However, there is a need to understand better the mechanism of action of this lignan to support the ethnopharmacological uses of the species. This work aimed to evaluate by in vivo and in silico analysis the mechanism of action of HB involved in its anxiolytic-like effects.

Experimental procedure

The effects of HB in mice were evaluated on light-dark box (LDB) and elevated plus maze (EPM) tests. The participation of 5-HT_1A receptor and the benzodiazepine site of GABA_A receptor was evaluated to investigate the possible mechanism of action. In silico tools were used to better elucidate the anxiolytic-like effects o

SUBMITTER: Gabriel de Oliveira M 

PROVIDER: S-EPMC9209824 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature