Tracking of Mammals and Their Fleas for Plague Surveillance in Madagascar, 2018-2019.

ABSTRACT: Plague, a zoonotic disease caused by the bacterium Yersinia pestis, remains a major public health threat in Madagascar. To better understand the risk of transmission to humans and to guide targeted plague prevention and control measures, a survey of Y. pestis infection and exposure in mammals and their fleas was implemented. Small mammals were captured in five districts of Madagascar ranging in levels of plague endemicity, as measured by notified cases, from none to active foci. Blood and spleen samples and fleas were collected from small mammals for the detection of anti-Y. pestis F1 antibodies by ELISA, F1 antigens by rapid diagnostic tests, and pla, caf1, and inv genes by polymerase chain reaction. Some rodent fleas were kept alive and reared in the insectary to assess susceptibility to

SUBMITTER: Rahelinirina S 

PROVIDER: S-EPMC9209941 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature