Pharmacokinetics of bisphenol A in humans following dermal administration.

ABSTRACT:

Background

Human exposures to bisphenol A (BPA) are widespread. The current study addresses uncertainties regarding human pharmacokinetics of BPA following dermal exposure.

Objective

To examine the absorption, distribution, metabolism and excretion of BPA in humans following dermal administration.

Methods

We dermally administered deuterated BPA (d6-BPA) to 10 subjects (6 men and 4 women) at a dose of 100 µg/kg over a 12-hour period and conducted blood and urine analysis from the beginning of dosing through a three- or six-day period. We present time-course serum and urine concentrations of total and unconjugated ("free") d6-BPA and used this information to calculate terminal half-life and area under the curve.

Results and conclusions

Detectable serum levels of

SUBMITTER: Sasso AF 

PROVIDER: S-EPMC9210257 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature