Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3.

ABSTRACT: Serotonin 2A receptors (5-HT_2ARs) mediate the hallucinogenic effects of psychedelic drugs and are a key target of the leading class of medications used to treat psychotic disorders. These findings suggest that dysfunction of 5-HT_2ARs may contribute to the symptoms of schizophrenia, a mental illness characterized by perceptual and cognitive disturbances. Indeed, numerous studies have found that 5-HT_2ARs are reduced in the brains of individuals with schizophrenia. However, the mechanisms that regulate 5-HT_2AR expression remain poorly understood. Here, we show that a physiologic environmental stimulus, sleep deprivation, significantly upregulates 5-HT_2AR levels in the mouse frontal cortex in as little as 6-8 h (for mRNA and protein, respe

SUBMITTER: Zhao X 

PROVIDER: S-EPMC9210263 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature