Late-Life Physical Activities Moderate the Relationship of Amyloid-β Pathology with Neurodegeneration in Individuals Without Dementia.

ABSTRACT:

Background

Physical activities (PA) have been suggested to reduce the risk of Alzheimer's disease (AD) dementia. However, information on the neuropathological links underlying the relationship is limited.

Objective

We investigated the role of midlife and late-life PA with in vivo AD neuropathologies in old adults without dementia.

Methods

This study included participants from the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease (KBASE). The participants underwent comprehensive clinical and neuropsychological assessment, [11C] Pittsburgh Compound B positron emission tomography (PET), [18F] fluorodeoxyglucose PET, and magnetic resonance imaging. Using the multi-modal brain imaging data, in vivo AD pathologies including global amyloid de

SUBMITTER: Sohn BK 

PROVIDER: S-EPMC9210327 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature