Ontology highlight
ABSTRACT:
SUBMITTER: Kim S
PROVIDER: S-EPMC9210496 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Kim Sunwhi S Kim Yong-Eun YE Song Inuk I Ujihara Yusuke Y Kim Namsoo N Jiang Yong-Hui YH Yin Henry H HH Lee Tae-Ho TH Kim Il Hwan IH
Cell reports 20220601 10
Dysfunctional sociability is a core symptom in autism spectrum disorder (ASD) that may arise from neural-network dysconnectivity between multiple brain regions. However, pathogenic neural-network mechanisms underlying social dysfunction are largely unknown. Here, we demonstrate that circuit-selective mutation (ctMUT) of ASD-risk Shank3 gene within a unidirectional projection from the prefrontal cortex to the basolateral amygdala alters spine morphology and excitatory-inhibitory balance of the ci ...[more]