Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials.

ABSTRACT: Numerous drug treatments that have recently entered the clinic or clinical trials have their genesis in zebrafish. Zebrafish are well established for their contribution to developmental biology and have now emerged as a powerful preclinical model for human disease, as their disease characteristics, aetiology and progression, and molecular mechanisms are clinically relevant and highly conserved. Zebrafish respond to small molecules and drug treatments at physiologically relevant dose ranges and, when combined with cell-specific or tissue-specific reporters and gene editing technologies, drug activity can be studied at single-cell resolution within the complexity of a whole animal, across tissues and over an extended timescale. These features enable high-throughput and high-content phenotypi

SUBMITTER: Patton EE 

PROVIDER: S-EPMC9210578 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature