Sexual transmission of Anopheles gambiae densovirus (AgDNV) leads to disseminated infection in mated females.

ABSTRACT:

Background

Anopheles gambiae densovirus (AgDNV) is an insect-specific, single-stranded DNA virus that infects An. gambiae sensu stricto (s.s.), the major mosquito species responsible for transmitting malaria parasites throughout sub-Saharan Africa. AgDNV is a benign virus that is very specific to its mosquito host and therefore has the potential to serve as a vector control tool via paratransgenesis (genetic modification of mosquito symbionts) to limit transmission of human pathogens. Prior to being engineered into a control tool, the natural transmission dynamics of AgDNV between An. gambiae mosquitoes needs to be fully understood. Additionally, improved knowledge of AgDNV infection in male mosquitoes is needed. In the study presented here, we examined the tissue tropism of AgDNV

SUBMITTER: Werling KL 

PROVIDER: S-EPMC9210586 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature