Neuroinflammation in the anterior cingulate cortex: the potential supraspinal mechanism underlying the mirror-image pain following motor fiber injury.

ABSTRACT:

Background

Peripheral nerve inflammation or lesion can affect contralateral healthy structures, and thus result in mirror-image pain. Supraspinal structures play important roles in the occurrence of mirror pain. The anterior cingulate cortex (ACC) is a first-order cortical region that responds to painful stimuli. In the present study, we systematically investigate and compare the neuroimmune changes in the bilateral ACC region using unilateral- (spared nerve injury, SNI) and mirror-(L5 ventral root transection, L5-VRT) pain models, aiming to explore the potential supraspinal neuroimmune mechanism underlying the mirror-image pain.

Methods

The up-and-down method with von Frey hairs was used to measure the mechanical allodynia. Viral injections for the designer receptors exclus

SUBMITTER: Li QY 

PROVIDER: S-EPMC9210588 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature