Glucose dysregulation and subclinical cardiac dysfunction in older adults: The Cardiovascular Health Study.

ABSTRACT:

Objective

We evaluated whether measures of glucose dysregulation are associated with subclinical cardiac dysfunction, as assessed by speckle-tracking echocardiography, in an older population.

Methods

Participants were men and women in the Cardiovascular Health Study, age 65+ years and without coronary heart disease, atrial fibrillation, or heart failure at baseline. We evaluated fasting insulin resistance (IR) with the homeostatic model of insulin resistance (HOMA-IR) and estimated the Matsuda insulin sensitivity index (ISI) and insulin secretion with an oral glucose tolerance test. Systolic and diastolic cardiac mechanics were measured with speckle-tracking analysis of echocardiograms. Multi-variable adjusted linear regression models were used to investigate associations of

SUBMITTER: Garg PK 

PROVIDER: S-EPMC9210635 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature