Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis.

ABSTRACT:

Background

Type I polyketide synthases (PKSs) are multifunctional enzymes responsible for the biosynthesis of a group of diverse natural compounds with biotechnological and pharmaceutical interest called polyketides. The diversity of polyketides is impressive despite the limited set of catalytic domains used by PKSs for biosynthesis, leading to considerable interest in deciphering their structure-function relationships, which is challenging due to high intrinsic flexibility. Among nineteen polyketide synthases encoded by the genome of Mycobacterium tuberculosis, Pks13 is the condensase required for the final condensation step of two long acyl chains in the biosynthetic pathway of mycolic acids, essential components of the cell envelope of Corynebacterineae species. It has been vali

SUBMITTER: Bon C 

PROVIDER: S-EPMC9210659 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature