Combined treatment with Rg1 and adipose-derived stem cells alleviates DSS-induced colitis in a mouse model.

ABSTRACT:

Background

Inflammatory bowel diseases, consisting of Crohn's disease and ulcerative colitis constitute chronic inflammatory conditions that may compromise the whole gastrointestinal tract as well as the colonic mucosa. Currently, there are no curative interventions for IBD, and all available treatments have side effects that limit their use. Adipose-derived stem cell (ADSC) treatment is a prospective treatment option for IBD. Previous findings indicated that ginsenoside (Rg1) dampened inflammatory diseases like colitis by inhibiting the binding of LPS to TLR4 on macrophages and restoring the Th17/Treg ratio. The purpose of this work was to investigate whether Rg1 can increase the influence of ADSC in a mouse model of colitis triggered by dextran sulfate sodium (DSS).

Methods

SUBMITTER: Zhang R 

PROVIDER: S-EPMC9210677 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature