The TetR-type regulator AtsR is involved in multidrug response in Corynebacterium glutamicum.

ABSTRACT:

Background

The TetR (tetracycline repressor) family is one of the major transcription factor families that regulate expression of genes involved in bacterial antimicrobial resistance systems. NCgl0886 protein, designated as AtsR, is a member of the TetR family identified in Corynebacterium glutamicum, which is conserved in several species of the genera Corynebacterium, also including the well-known pathogen C. diphtheriae. AtsR is located at no far upstream of the identically oriented ncgl0884 gene, encoding a putative multidrug efflux pump protein, and in the same operon with ncgl0887, encoding a resistance, nodulation and cell division (RND) superfamily drug exporter. However, the role of AtsR is not clearly understood.

Results

Here we showed that dimeric AtsR directly rep

SUBMITTER: Su T 

PROVIDER: S-EPMC9210681 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature